Dipotassium Glycyrrhizate

This water-soluble salt is derived from glycyrrhizic acid, the main sweet component of liquorice root. Converting it into a potassium salt improves its solubility and suitability for water-based serums and emulsions. It is a popular soothing ingredient for sensitive skin and is often combined with panthenol, oats or niacinamide.

Dipotassium Glycyrrhizate suppresses inflammatory signals, helps reduce redness and uncomfortable itching, and helps soothe skin with a weakened barrier. It also has antioxidant and mild antimicrobial properties. It is neither a corticosteroid nor a treatment for eczema, but a gentle cosmetic ingredient that supports the skin. In a hydrating formulation, it may reduce reactivity caused by dryness, cleansing or environmental stress.

We recommend it for sensitive, dry, reactive, acne-prone skin and skin prone to redness. It is also suitable for use in aftershave and after-sun products, or when using retinoids. If you have diagnosed dermatitis, it should be part of a simple skincare routine approved by a dermatologist. An allergy to liquorice is rare, but possible.

A clinical study in adults with mild to moderate atopic dermatitis showed that regular use of an emollient containing dipotassium glycyrrhizate reduced symptoms and the frequency of flare-ups (Clinical, Cosmetic and Investigational Dermatology, 2025). The result applied to the complete emollient formulation, so the effect cannot be attributed solely to one ingredient.

It is commonly used at a concentration of approximately 0,1 to 1 per cent. It is water-soluble and suitable for the cool-down phase. The formulation should have a slightly acidic to neutral pH. For sensitive skin, it is important to minimise fragrance and harsh preservative or exfoliating systems.

Its soothing effect is best achieved in a simple routine without excessive fragrance, essential oils or layering several acids at the same time. If your skin is reactive, it is sensible to test a new product on a small area first. Persistent burning, significant flaking or worsening redness are not signs of normal adjustment and are reasons to stop using the product and consult a dermatologist. Consistent daily sun protection is also important.