AnnonaSense CLR

This bioactive extract is obtained from an edible subtropical fruit originally grown in South America. The manufacturer uses a standardised process to preserve molecules that influence stress signalling in the skin. This plant-derived ingredient is mainly used in products for sensitive skin, uncomfortable itching and visible signs of stress-related fatigue.

AnnonaSense CLR acts on signalling involving substance P, cytokines and the IL-31RA receptor. The aim is to reduce itching, reactivity and redness that worsen with psychological or environmental stress. The extract does not act as an anaesthetic, but supports a more balanced skin response. It may improve skin comfort and appearance, particularly as part of a simple, fragrance-free formula that supports the skin barrier.

We recommend it for sensitive, reactive, dry and stressed skin that frequently itches, stings or reacts to changes in temperature. It may also be suitable for rosacea-prone skin, provided the product as a whole contains no irritating ingredients. It is not intended as a treatment for atopic dermatitis or psychological stress, but as supportive skincare.

In a supplier clinical study involving volunteers with sensitive skin and high levels of daily stress, perceived skin comfort and appearance improved, itching decreased and measurements suggested lower systemic cortisol production (CLR Skin-Brain Study). As this is a proprietary extract and the data are manufacturer-funded, claims should be tied to the recommended concentration.

The supplier usually recommends a concentration of approximately 1 to 3 per cent. The extract is added during the cool-down phase at a mild pH. In products for sensitive skin, it makes sense to combine it with betaine, panthenol, oats or barrier lipids and leave out fragrance.

The soothing effect is best supported by a simple routine without excessive fragrance, essential oils or layering several acids at once. For reactive skin, it is sensible to test a new product on a small area first. Persistent stinging, pronounced flaking or worsening redness are not signs of normal adjustment and are reasons to stop using the product and consult a dermatologist. Consistent daily sun protection is also important.