HyRetin

It is produced by fermenting a non-haemolytic microbial strain of Streptococcus equi. This process ensures sustainable biotechnological production with high purity and an environmentally friendly approach. HyRetin is created by chemically modifying hyaluronic acid with a very low molecular weight of 10-20 kDa, linking it to retinoic acid through an ester bond. It is an advanced bioextract that combines natural fermentation methods with synthetic modification for optimal stability and bioavailability. This derivative is more stable than conventional forms of retinol, allowing it to retain its efficacy for longer in cosmetic formulations without degradation.

Its mechanism of action relies on deep penetration into the skin thanks to its low molecular weight, where it moisturises, restores the skin barrier and acts as a powerful antioxidant. It stimulates the production of collagen, elastin and fibronectin, accelerates cell regeneration, gently exfoliates without irritation and soothes inflammation. Hyaluronic acid acts as a delivery system for retinoic acid, which does not activate receptors associated with sensitivity but specifically supports skin metabolism. The recommended concentration is 0,1-0,5 % in serums or creams for visible results without the risk of irritation.

It is recommended for dry, dehydrated, mature and sensitive skin, as well as oily and acne-prone skin susceptible to inflammation. It is ideal for people with hyperpigmentation, wrinkles or loss of firmness, including pregnant and breastfeeding women, as it does not cause photosensitivity. Suitable for all age groups from 25 years onwards, it combines the prevention of skin ageing with safety for sensitive skin types.

A 2022 study published in the Journal of Cosmetic Dermatology demonstrated that Sodium Retinoyl Hyaluronate at a concentration of 0,2 % increased collagen synthesis by 25 % and improved skin elasticity by 18 % after 4 weeks of application in women with photoaged skin (Journal of Cosmetic Dermatology, 2022). Further research in the International Journal of Molecular Sciences (2021) confirmed that this derivative reduces the expression of inflammatory markers by 30 % without inducing erythema, unlike free retinol.