CutiBiome CLR™

A unique blend of natural substances with powerful cleansing and anti-inflammatory properties that actively fights acne-causing bacteria. Active ingredients derived from black cumin, magnolia, manuka and chaulmoogra have antimicrobial properties and minimise inflammation in the skin. These ingredients are obtained from plants such as manuka (Leptospermum scoparium) from New Zealand, magnolia bark (Magnolia officinalis) from Asia, black pepper seed extract (Piper nigrum) and oil from manuka branches, all combined with the carrier octyldodecanol. These are organic extracts of natural origin, specially developed for cosmetics without synthetic additives, ensuring a gentle and effective approach to skincare.

It works as a cleansing complex with an antimicrobial mechanism that suppresses the growth of Cutibacterium acnes (formerly P. acnes), minimising inflammatory processes by reducing both primary inflammation and inflammation caused by these bacteria. It has anti-inflammatory properties, regulates sebum production, reduces comedones, pustules and spots, and acts as a powerful antioxidant that protects against oxidative stress. In vitro and in vivo tests demonstrate the blend's synergistic effect in reducing the growth of two different strains of C. acnes. The recommended concentration in formulations is typically 1-5 %, providing optimal efficacy without irritation.

It is particularly recommended for oily, combination and acne-prone skin, where it regulates excess sebum production and reduces inflammation. It is also suitable for sensitive skin prone to spots, dehydrated skin with an impaired barrier, and mature skin, where antioxidants slow down ageing. It is not ideal for extremely dry skin without excess sebum concerns, as its cleansing effects may need to be balanced with additional hydrating ingredients. Regular use strengthens the skin, leaving it clearer, less prone to breakouts and more elastic.

In vitro studies have shown that CutiBiome CLR™ at a concentration of 2 % inhibits the growth of virulent phylotypes of Cutibacterium acnes by more than 90 % and significantly reduces acne-related inflammation (according to tests by the manufacturer CLR). In vivo tests on volunteers showed a 40-60 % reduction in the number of comedones and pustules after 4 weeks of application in creams (results from clinical trials listed in the product specifications). Another study confirmed a 30 % reduction in sebum in individuals with oily skin (Journal of Cosmetic Science, 2018, on similar antimicrobial complexes with manuka).